What is clear is that Alzheimer's develops as a result of a complex cascade of biological processes that take place over many years inside the brain. The answers to this central question are evolving as research provides more information. Right now, age is the primary risk factor for Alzheimer's, along with family history (discussed under genetics). More women than men have Alzheimer's, but this is likely because women generally live longer than men; the incidence by age is similar among men and women. Education level and previous history of head trauma are also generally agreed upon as probable risk factors for Alzheimer's. Estrogen replacement therapy after menopause and the use of certain groups of drugs, including non-steroidal anti-inflammatory drugs (NSAIDs) and cholesterol-lowering drugs called statins, may also impact

Age
The greatest known risk factor for Alzheimer’s is increasing age. Most individuals with the disease are 65 or older. The likelihood of developing Alzheimer’s doubles about every five years after age 65. After age 85, the risk reaches nearly 50 percent.

Family history
Another risk factor is family history. Research has shown that those who have a parent, brother or sister, or child with Alzheimer’s are more likely to develop Alzheimer’s. The risk increases if more than one family member has the illness. When diseases tend to run in families, either heredity (genetics) or environmental factors or both may play a role.

Genetics (heredity)
Scientists know genes are involved in Alzheimer’s. There are two categories of genes that can play a role in determining whether a person develops a disease.

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